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KMID : 0370220110550010011
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Yakhak Hoeji
2011 Volume.55 No. 1 p.11 ~ p.15
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Antibacterial Activity of Zabofloxacin, a Novel Fluoroquinolone, against Gram-Positive Bacteria
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Park Hee-Soo
Jung Sung-Ji
Jeong Ji-Woong
Choi Dong-Rack
Kim Hyo-Hyun
Choi Eung-Chil
Kwak Jin-Hwan
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Abstract
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Zabofloxacin is a novel broad spectrum fluoroquinolone with excellent anti-pneumococcal activity. We investigated the in vitro activity of zabofloxacin against clinical isolates of gram-positive bacteria and the in vivo activity against systemic infection in mice. Zabofloxacin was very active against gram-positive bacteria except QRSA (Quinolone-resistant S. aureus) and VRE(Vancomycin-resistant Enterococci). Especially, zabofloxacin was extremely potent against clinical isolates of Streptococci. Zabofloxacin was as active as gemifloxacin against systemic infection in mice. In view of its improved antibacterial activities against gram-positive bacteria and good pharmacokinetic profiles in animals, the clinical usefulness of zabofloxacin should be established by further studies.
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KEYWORD
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zabofloxacin, fluoroquinolone, gram-positive bacteria, MIC, in vivo activity
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